CLEVELAND — — The blindside hit that finally took out Baker Mayfield came off the field.

The Cleveland quarterback had toughed it out for months, playing with a fractured left shoulder, bruised knee and heel issue. He was back to being himself, mostly healed.

“This is the best I’ve felt since Week 2,” Mayfield said following last week’s win over Baltimore.

Now, he’s sacked. And he’s hardly alone.

Mayfield is one of several Cleveland starters — along with coach Kevin Stefanski — expected to miss Saturday’s game against the Las Vegas Raiders after testing positive for COVID-19 during a week in which the virus ran rampant across the NFL, leading to an adjustment in the league’s health protocols.

As of Thursday, the Browns (7-6) had 18 players on the COVID-19 reserve list and were prepared to head into a game they need to win in order to keep their playoff hopes intact without Mayfield, top wide receiver Jarvis Landry, two starting offensive linemen and two starting safeties.

And two coaches.