Matchup: No. 6 Buffalo Bills vs. No. 1 Denver Broncos

Storyline: The Bills earned their place with a road Wild Card win and now travel to Empower Field at Mile High to face the AFC’s top seed. This is a rematch of a recent playoff game between these franchises, and Denver’s strong regular-season home performance adds to the challenge for Buffalo.

Key Factors: Denver’s defense and altitude advantage; Buffalo dealing with key injuries and shorter rest after a Monday Wild Card game.